As the 2014 NATO drawdown from Afghanistan approaches, the EU increasingly focuses on preventing potential spillover effects on Central Asia. The Union wishes to further its cooperation with the wider region. But to succeed, it will have to develop a clearer strategy to avoid condoning the repressive policies and opaque interests of the Central Asian governments. The EU should focus on a few well-chosen areas and prioritise the involvement of local actors, in particular civilian stakeholders, who are the only vectors of long-term sustainable solutions. This paper addresses the Central Asia-Afghanistan relationship, analyses the impact of post-2014 changes to the security context and looks at the EU’s opportunities to foster regional dynamics.